Rizwan Khan (Shahrukh Khan) is a Muslim child who grew up with his brother Zakir (Jimmy Shergill) and his mother Razia Khan (Zarina Wahab) in a middle-class family in the Borivali section of Mumbai. Rizwan is different from other children, however. He has certain gifts, particularly a special ability to repair mechanical things. His difference leads to special tutoring from a reclusive scholar and extra attention from his mother, both of which lead to heightened jealousy from his brother Zakir, who eventually leaves his family for a life in the United States.

Despite this resentment, as an adult Zakir sponsors Rizwan to come and live with him in San Francisco after the death of their mother. It is at this time that Zakir's wife, Haseena (Sonya Jehan) diagnoses Rizwan with Asperger's syndrome. Rizwan also begins to work for Zakir, and in the process he meets a Hindu woman, Mandira (Kajol) and her young son, Sameer or Sam (Yuvaan Makaar), from a previous marriage. Mandira is a hairdresser. Despite Zakir's hostility to the match, Khan and Mandira marry and settle down in the fictional town of Banville. Both Mandira and Sameer take Rizwan's last name as their own. They also live next door to the Garrick family. Sameer is close to their young son, Reese (Kenton Duty and Michael Arnold) while Mark (Dominic Renda) is a reporter and Sarah (Katie A. Keane) is a friend of Mandira.


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